Essays about: "immune checkpoint"

Found 3 essays containing the words immune checkpoint.

  1. 1. Structural features underlying antigen presentation by the non-classical MHC class Ib molecule Qa-1b

    University essay from KTH/Proteinvetenskap

    Author : Lejla AI-Tamimi; [2022]
    Keywords : immune checkpoint; NKG2A; MHC class Ib; Qdm; antibody; crystal structure;

    Abstract : Blockering av NKG2A receptorn på NK - och CD8+ T celler med en anti-NKG2A antikropp, medför en aktivering av cytolytisk aktivitet, och är en lovande immunkontrollpunkt i immunterapi mot cancer. Nyligen har en TCR-liknande antikropp, EXX1, som binder till liganden för NKG2A receptorn, Qa-1b - en icke-klassisk MHC klass Ib molekyl i möss -studerats i tumör modeller in vitro. READ MORE

  3. 2. Studying the Whole Through the Sum of its Parts: Comparing CD8+ Tumour Infiltrating Lymphocytes in Three Types of Human Carcinoma

    University essay from Lunds universitet/Läkarutbildningen

    Author : Gustav Christensson; [2020]
    Keywords : Cancer; immunotherapy; scRNA-seq; tumour-infiltrating lymphocyte; CD8 T cells; Medicine and Health Sciences;

    Abstract : Background: Tumour-infiltrating lymphocytes (TILs) that persist in chronic infections gradually lose their effector functions and become “exhausted”. Immune checkpoint blockade is an emerging cancer treatment which aims to induce exhausted TILs into regaining their effector function to fight neoplastic cells. READ MORE

  4. 3. Investigation Of Human Cancer Immune Interaction Using In Vitro Assays

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Irineos Papakyriacou; [2020]
    Keywords : Cancer immunotherapy; nivolumab; durvalumab;

    Abstract : Cancer immunotherapy, including immune checkpoint blocking antibodies are important components for treatment of patients with various types of cancer as they enhance the ability of the immune system to fight tumours. However, tumor cells have the ability to develop resistance to a variety of transitional therapies such as chemotherapy. READ MORE