Essays about: "morphological profiles"

Showing result 1 - 5 of 11 essays containing the words morphological profiles.

  1. 1. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

    University essay from Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Author : Erik Everett Palm; [2023]
    Keywords : bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

    Abstract : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. READ MORE

  3. 2. Predicting morphological effect of compounds on COVID-19 infected cells

    University essay from Uppsala universitet/Läkemedelsdesign och läkemedelsutveckling

    Author : Viktor Öhrner; [2023]
    Keywords : QSAR; ML; AI; bioinformatics; COVID-19; morphological profiles;

    Abstract : The cost of developing new drugs is high and the aim of computer-assisted drug discovery is to reduce that development cost, either through virtual screening or generating novel compounds. System biology is one approach to drug discovery where the response of a biological system is the subject of study, instead of drug target interaction. READ MORE

  4. 3. Phenotypic profiling and drug screening in Rhabdomyosarcoma cell lines

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Laura Martina Lang; [2022]
    Keywords : Rhabdomyosarcoma; Phenotypic profiling; Phenotypic drug screening;

    Abstract : Rhabdomyosarcoma (RMS) is a type of soft tissue sarcoma that mainly occurs in children. RMS can be divided into two subtypes embryonal (ERMS) and alveolar (ARMS). The ARMS subtype can be especially aggressive when a balanced chromosomal translocation is present. READ MORE

  5. 4. Improving ligand-based modelling by combining various features

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Abir Omran; [2021]
    Keywords : Machine learning; QSAR; Support Vector Machine; Morphological Profiles; Conformal Prediction;

    Abstract : Background: In drug discovery morphological profiles can be used to identify and establish a drug's biological activity or mechanism of action. Quantitative structure-activity relationship (QSAR) is an approach that uses the chemical structures to predict properties e.g., biological activity. READ MORE

  6. 5. Identification of changes in biomarkers relevant for breast cancer biology occurring in a novel 3D-Biosilk model

    University essay from KTH/Proteinvetenskap

    Author : Emmy Ståhl; [2021]
    Keywords : 3D-Biosilk; breast cancer; 3D cell culture; recombinant spider silk; ZO-1; 3D-Biosilk; bröstcancer; 3D cellkultur; rekombinant spindeltråd; ZO-1;

    Abstract : Bröstcancer är den vanligaste formen av cancer som drabbar kvinnor. Det är en heterogen och komplex sjukdom som består av flera undergrupper, var och en med distinkt morfologi och kliniska implikationer [1]. För att modellera och studera cellbiologi, vävnadsmorfologi, molekylära mekanismer och läkemedels effekter används cellkulturer [2]. READ MORE