Essays about: "pharmacokinetics"

Showing result 6 - 10 of 43 essays containing the word pharmacokinetics.

  1. 6. Population Pharmacokinetics of Linezolid for Optimization of the Treatment for Multidrug Resistant Tuberculosis

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Viktor Hansen; [2022]
    Keywords : tuberculosis; drug resistance; pharmacometrics; pharmacokinetics; pop-pk; south africa; non linear mixed effects modelling; nlme;

    Abstract : Tuberculosis is one the leading causes of death globally and was before the COVID-19 pandemic the leading cause of death from a single infectious agent. Developing active tuberculosis is life threatening and therefore is the rise of drug-resistant tuberculosis alarming as this risk causing current treatments to become ineffective. READ MORE

  3. 7. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Osama Qutishat; [2022]
    Keywords : Machine learning; pharmacometrics; Neural networks; pop-pk;

    Abstract : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. READ MORE

  4. 8. Pharmacokinetic changes of meropenem in sepsis patients: A Comparative Review

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Rami Osman Abubaker; [2022]
    Keywords : ;

    Abstract : Background: Sepsis is a life-threatening organ dysfunction occurring during infections. Meropenem is a hydrophilic β-lactam carbapenem antibiotic. Its pharmacokinetic parameters are expected to change due to sepsis-induced physiological alterations and will thus require altered dosing strategies for optimal treatment of sepsis patients. READ MORE

  5. 9. Automatic Development of Pharmacokinetic Structural Models

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alzahra Hamdan; [2022]
    Keywords : pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Abstract : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. READ MORE

  6. 10. Identifiability of pharmacological models from data

    University essay from Lunds universitet/Institutionen för reglerteknik

    Author : Amina Gojak; [2021]
    Keywords : Technology and Engineering;

    Abstract : In order to automate anaesthesia in patients using propofol, closed-loop control systems with models that describe the time course of the drug effects on the body are required, usually being represented by pharmacokinetics and pharmacodynamics(PKPD). This thesis focused on evaluating parameter identifiability for the PK part of the model, using a model proposed by Eleveld et al. READ MORE