Essays about: "pyrazinamide"

Found 2 essays containing the word pyrazinamide.

1. 1. Individualization of fixed-dose combination regimens : Methodology and application to pediatric tuberculosis

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Gunnar Yngman; [2015]
   Keywords : pharmacometrics; pharmacokinetics; PK; population pharmacokinetics; optimal design; FDC; fixed-dose combination; pediatrics; tuberculosis; rifampicin; pyrazinamide; isoniazid; ethambutol; modeling; simulation; estimation; allometric scaling; stochastical simulation and estimation; NONMEM; MATLAB; FO; FOCE; Expectation-Maximization algorithm; importance sampling; Nelder-Mead method; logistic function; discontinuity; euclidean distance; Sammon mapping; global minimum; local minima;

   Abstract : Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. READ MORE

3. 2. Spoligotyping and pncA sequencing as an epidemiological marker for Pyrazinamide resistant M. Tuberculosis

   University essay from

   Author : Joanna Daffy; [2012]
   Keywords : ;

   Abstract : .... READ MORE