Essays about: "Dynamic light scattering DLS"

Showing result 1 - 5 of 22 essays containing the words Dynamic light scattering DLS.

1. 1. Methods to study device induced aggregation of proteins

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Marie Therese von Wowern; [2023]
   Keywords : protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

   Abstract : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. READ MORE

3. 2. Investigation on Liquid-Liquid Phase Separation in Immunoglobulin G Solutions

   University essay from Stockholms universitet/Fysikum

   Author : Lovisa Jansson; [2023]
   Keywords : Protein; Liquid-Liquid Phase Separation; Microscopy; Light Scattering;

   Abstract : Liquid-liquid phase separation (LLPS) is an important phenomenon in soft condensed matter that explains many properties of membraneless organelles in living cells. The research on this topic is, therefore, a field with a wide range of applications such as biopharmacy and biomaterials. READ MORE

4. 3. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

   University essay from Lunds universitet/Kemiteknik (CI)

   Author : Owais Khalil; [2023]
   Keywords : Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

   Abstract : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. READ MORE

5. 4. Green Coacervates for Pharma and Food

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Izabella Imets; Andreas Vallin; [2022]
   Keywords : MSc; coacervate; biosurfactant; biopolymer; SAXS; DLS; elliposometry; pharmaceutical technology; Technology and Engineering;

   Abstract : Anionic biosurfactant-cationic biopolymer systems were investigated to identify and characterize a coacervation window. The characterization of the systems was performed with dynamic light scattering, small angle x-ray scattering and in-situ ellipsometry. READ MORE

6. 5. Aggregation mechanisms of proteins in liquid formulations

   University essay from KTH/Kemi

   Author : Amanda Hamrin; [2022]
   Keywords : Protein aggregering; seedingmekanism; dynamic light scattering; differential scanning calorimetry; Somatropin; monoklonal antikropp; Protein aggregation; seeding mechanism; dynamic light scattering; differential scanning calorimetry; somatropin; monoclonal antibody;

   Abstract : Biologiska läkemedel har under det senaste århundradet utökats, och under de senaste 25 åren så har proportionen av godkända biologiska läkemedel har ökat för behandlingen av sjukdomar, vaccin, och diagnostik. Det finns flera olika mekanismer för protein aggregering, och en av dessa är seeding, vilket innebär aggregering inducerat av tillsatta aggregat eller förekomsten av strukturförändringar i proteinet. READ MORE