Essays about: "SAXS"

Showing result 1 - 5 of 26 essays containing the word SAXS.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Author : Elina Edidovica; [2024]
    Keywords : Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Abstract : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. READ MORE

  3. 2. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    University essay from KTH/Tillämpad fysik

    Author : Samuel Eriksson Lidbrink; [2023]
    Keywords : AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Abstract : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. READ MORE

  4. 3. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    University essay from Lunds universitet/Kemiteknik (CI)

    Author : Owais Khalil; [2023]
    Keywords : Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Abstract : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. READ MORE

  5. 4. Phenol-Protein Solution Stability

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Johan Sjölund; [2022]
    Keywords : Phenol; Protein; Proteins; Lysozyme; Betalactoglobulin; Trastuzumab; Lipase; GAZ; GA-Z; Palifermin; Titration; Probedrum; Pharmaceutical Technology; Chemistry;

    Abstract : Phenol is a commonly used preservative in pharmaceutical protein solutions. It is compatible with most proteins but can cause aggregation and denaturation at higher concentrations or in more sensitive proteins. READ MORE

  6. 5. Green Coacervates for Pharma and Food

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Izabella Imets; Andreas Vallin; [2022]
    Keywords : MSc; coacervate; biosurfactant; biopolymer; SAXS; DLS; elliposometry; pharmaceutical technology; Technology and Engineering;

    Abstract : Anionic biosurfactant-cationic biopolymer systems were investigated to identify and characterize a coacervation window. The characterization of the systems was performed with dynamic light scattering, small angle x-ray scattering and in-situ ellipsometry. READ MORE