Essays about: "Fragment based drug discovery"
Found 5 essays containing the words Fragment based drug discovery.
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1. Fragment-screening by X-ray crystallography of human vaccinia related kinase 1
University essay from Linköpings universitet/Institutionen för fysik, kemi och biologiAbstract : Fragment-screening by X-ray crystallography (XFS) is an expensive and low throughput fragment drug discovery screening method, and it requires a lot of optimization for each protein target. The advantages with this screening method are that it is very sensitive, it directly gives the three-dimensional structure of the protein-fragment complexes, and false positives are rarely obtained. READ MORE
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2. Fragment screening using WAC towards new SMARCA4 inhibitors
University essay from Lunds universitet/Centrum för analys och syntesAbstract : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. READ MORE
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3. Production and characterization of LSD1 and LSD2 for fragment based drug discovery
University essay from Uppsala universitet/BiokemiAbstract : .... READ MORE
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4. Synthesis of Substituted Pyrrolidines
University essay from KTH/Skolan för kemivetenskap (CHE)Abstract : The task of medicinal chemists in a drug discoveryproject is to synthesize/design analogues to the screening hits, simultaneouslyincreasing target potency and optimizing the pharmacological properties. This requires a wide selection of moleculesto be synthesized, where both synthetic feasibility and price of startingmaterials are of great importance. READ MORE
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5. Weak Affinity Chromatography : Evaluation of Different Silica Supports for Protein Immobilizationand Effect of Mobile Phases Regarding Retentionand Non-specific Binding
University essay from Institutionen för naturvetenskap, NVAbstract : Fragment based lead discovery (FBLD), where libraries of small fragments are screened andlater on developed to lead compounds, is an alternative to the classical drug discovery methods such as high trough-put screening. Weak affinity chromatography (WAC) is a new promising approach to the screening process of FBLD. READ MORE
