Essays about: "Fusion Protein"

Showing result 6 - 10 of 40 essays containing the words Fusion Protein.

1. 6. Expression of the Sloppymerase™ in NIH/3T3 Cells: Exploring the Versatility of an Error Prone Fusion Polymerase

   University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Author : Mikaela Mattsson; [2021]
   Keywords : ;

   Abstract : The aim of this project is to assess the versatility of the Sloppymerase by performing stable transfection in NIH/3T3 cells and decide whether this cell line can be a candidate for further research on the Sloppymerase as a cancer model. The American cancer society predicts 1,806,590 new cancer cases in the US in 2020. READ MORE

3. 7. Formulation development of a recombinant VAR2-antiCD3 protein for cancer immunotherapy

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

   Author : Maja Warlin; Frida Hallberg; [2021]
   Keywords : immunotherapy; cancer; pharmaceuticals; proteins; analytical techniques; molecular biotechnology; formulation; life science; engineering; pharmaceutical technology; Technology and Engineering;

   Abstract : The use of immunotherapy for treating cancer has received a lot of attention in the recent years. The therapy is based on activating or deactivating the patient’s own immune system to help fight the disease. One way of doing this, is using bispecific molecules that can target both cancer cells and T-cells simultaneously. READ MORE

4. 8. Search for the Argonaute protein that governs miRNA regulation in Dictyostelium discoideum

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Miranda Åström; [2021]
   Keywords : Argonaute proteins; RNA interference; miRNA; 3xFLAG-tag;

   Abstract : MicroRNAs are small non-coding RNAs that regulate gene expression through RNA interference. These small RNAs enact gene silencing by forming a RNA-inducing silencing complex together with the effector protein Argonaute. The function of the Argonautes in the social amoeba Dictyostelium discoideum is not yet fully understood. READ MORE

5. 9. Validation and optimization of multiplexInSitu PLA for signalling pathway analysis

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Tanay Kumar Sinha; [2021]
   Keywords : Chronic myeloid leukemia Tyrosine kinase inhibitors Proximity ligation assay Cross-reactivity Padlock Template;

   Abstract : With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. READ MORE

6. 10. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins

   University essay from KTH/Proteinvetenskap

   Author : Carl Olsson; [2021]
   Keywords : Post synaptic density protein 95; PDZ-domains; N-methyl-D-aspartate receptor; NMDAR hypofunctional hypothesis; GluN2b; Differential scanning fluorimetry; Surface plasmon resonance; Fragment based drug design; Assay development;

   Abstract : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. READ MORE