Essays about: "Kinase Domain"

Showing result 1 - 5 of 6 essays containing the words Kinase Domain.

  1. 1. Effects of phosphorylation on the ADP-ribosylation activity of PARP16

    University essay from Lunds universitet/Kemiska institutionen

    Author : Virginia Martín Cristóbal; [2023]
    Keywords : ADP-ribosylation; Kinases; PARP16; Phosphorylation; UPR biochemistry; Biochemistry; Chemistry;

    Abstract : PARP16/ARTD15 is an intracellular mono-ADP-ribosyltransferase that catalyzes auto- and heteromodification by transfer of a single ADP-ribose moiety. It belongs to the ADP-ribosyltransferase (ART) superfamily. READ MORE

  3. 2. Recombinant production of spider silk for enzymatic phosphorylation

    University essay from KTH/Proteinvetenskap

    Author : Kristel Jaiu; [2022]
    Keywords : Caddisfly larval silk; FN-4RepCT; phosphorylation; protein kinase A; recombinant spider silk; Nattsländesilke; FN-4RepCT; fosforylering; proteinkinas A; rekombinant spindeltrådsilke;

    Abstract : Ett rekombinant framställt miniatyrspindelsilkeprotein, funktionaliserat med ett Arg-Gly-Asp-motiv som finns i fibronektin, FN-4RepCT, har använts för många olika bioteknologiska tillämpningar, som vävnadsteknik och cellodling, i form av fibrer, filmer och skum. FN-4RepCT kan produceras i Escherichia coli, och det interagerar spontant med sig självt och bildar fibrer under fysiologiska förhållanden. READ MORE

  4. 3. The Effects of ACK1 and Cell Density on ErbB3

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Julia Svensson; [2021]
    Keywords : ;

    Abstract : The ErbB family of receptors are involved in signalling relating to cell proliferation and differentiation through activation of pathways such as PI3K and MAPK. Their overexpression is often found in different cancer types and therefore, their expression is under tight regulation. READ MORE

  5. 4. Validation and optimization of multiplexInSitu PLA for signalling pathway analysis

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Tanay Kumar Sinha; [2021]
    Keywords : Chronic myeloid leukemia Tyrosine kinase inhibitors Proximity ligation assay Cross-reactivity Padlock Template;

    Abstract : With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. READ MORE

  6. 5. Studying the Oligomerization of the Kinase Domain of Ephrin type-B Receptor 2 Using Analytical Ultracentrifugation and Development of a Program for Analysis of Acquired Data

    University essay from Linköpings universitet/Kemi; Linköpings universitet/Tekniska högskolan

    Author : Alexander Lundberg; [2014]
    Keywords : Ephrin type-B receptor 2; EphB2; Analytical Ultracentrifugation; Oligomerization; Kinase Domain; Protein Expression; Protein Purification; Programming; Analysis of Data;

    Abstract : Ephrin type-B receptor 2 (EphB2) is a receptor tyrosine kinase which phosphorylates proteins and thereby regulates cell migration, vascular development, axon guidance synaptic plasticity, and formation of borders between tissues. It has been seen overexpressed in several cancers, which make it an interesting protein to study. READ MORE