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Showing result 1 - 5 of 16 essays matching the above criteria.

  1. 1. The effect of GSK-3 inhibitor SB216763 on the expression and secretion of IL-8 in THP-1 ASC GFP macrophages cells

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Umaimah Hassen; [2022]
    Keywords : ;

    Abstract : Inflammation is a part of the innate immune system. It protects the body against foreign invaders such as bacteria and viruses. Inflammation helps to restore the body by removing harmful stimuli and starting the healing process. READ MORE

  3. 2. The Effects of ACK1 and Cell Density on ErbB3

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Julia Svensson; [2021]
    Keywords : ;

    Abstract : The ErbB family of receptors are involved in signalling relating to cell proliferation and differentiation through activation of pathways such as PI3K and MAPK. Their overexpression is often found in different cancer types and therefore, their expression is under tight regulation. READ MORE

  4. 3. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Kajsa Andreasson Dahlgren; [2021]
    Keywords : Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Abstract : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. READ MORE

  5. 4. The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

    University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

    Author : Karl-Hermann Sielinou Kamgang; [2020]
    Keywords : ;

    Abstract : Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. READ MORE

  6. 5. EXPRESSION OF THE THREE PROTO-ONCOGENES, EGFR, MEK AND B-RAF AFTER TRANSFECTION INTO HUMAN CELLS AND THEIR DETECTION BY MASS SPECTROMETRY

    University essay from Malmö högskola/Fakulteten för hälsa och samhälle (HS)

    Author : Jimmy Olum; [2016]
    Keywords : EGFR; MEK1; BRAF; Mass spectrometry; Gateway Technology; pLenti 6.3 V5.;

    Abstract : When activated by growth factors and mitogens, cellular receptors like EGFR become activated and transmit signals from the cell surface through the MAPK pathway into the nucleus of the cell, in order to elicit a cellular response like growth, apoptosis, proliferation, and survival. Over activation of EGFR even without receptor binding and members of the MAPK pathways like BRAF and MEK1 have been reported in tumorigenesis. READ MORE