Essays about: "biological drugs"

Showing result 11 - 15 of 44 essays containing the words biological drugs.

  1. 11. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Micaela Andersson; [2022]
    Keywords : Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

    Abstract : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. READ MORE

  3. 12. Development of a novel quantitative PCR analysis method for HIV-1

    University essay from Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Author : Anna-Malin Hallberg; [2021]
    Keywords : HIV; PCR; primers; probes; virus; detection; blood plasma; pathogen; biological pharmaceutical; protein-based pharmaceutical; genotype; subtype; RT qPCR; extraction; TaqMa; RNA virus; cross-dimer; applied biochemistry; tillämpad biokemi; Biology and Life Sciences; Technology and Engineering; Chemistry;

    Abstract : Biological pharmaceuticals are the answer to many severe diseases of today’s society. Some of these are protein-based drugs and can be produced from human blood plasma. In order to guarantee the safety of patients, absence of any pathogens needs to be ensured. READ MORE

  4. 13. Predicting safe drug combinations with Graph Neural Networks (GNN)

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Amirhossein Amanzadi; [2021]
    Keywords : Drug Combination; Polypharmacy Side Effects; Graph Neural Networks;

    Abstract : Many people - especially during their elderly - consume multiple drugs for the treatment of complex or co-existing diseases. Identifying side effects caused by polypharmacy is crucial for reducing mortality and morbidity of the patients which will lead to improvement in their quality of life. READ MORE

  5. 14. Temporal Multivariate Distribution Analysis of Cell Shape Descriptors

    University essay from Umeå universitet/Institutionen för fysik

    Author : Amanda Krantz; [2021]
    Keywords : ;

    Abstract : In early drug discovery and the study of the effects of new chemical compounds on cancer cells, the change in cell shape over time provides vital information about cell health. Live-cell image analysis systems can be used to extract cell-shape describing parameters of individual cells during exposure to new drugs. READ MORE

  6. 15. Expression & affinity analysis of recombinant RX against pathogenic α-synuclein

    University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Author : Isak Simon; [2021]
    Keywords : Parkinson’s disease; α-synuclein; ELISA; Biological drugs; Protein-based drugs;

    Abstract : Background In the as of yet uncurable Parkinson´s disease aggregation of α-syn is an accelerator of pathogenesis. Oligomers of α-synuclein is considered to be neurotoxic hence blocking the endocytosis of aggregated α-syn is possibly a way of preventing pathogenesis. READ MORE