Essays about: "drug discovery process"

Showing result 6 - 10 of 23 essays containing the words drug discovery process.

1. 6. Multi-task regression QSAR/QSPR prediction utilizing text-based Transformer Neural Network and single-task using feature-based models

   University essay from Linköpings universitet/Statistik och maskininlärning

   Author : Spyridon Dimitriadis; [2021]
   Keywords : multi-task regression; QSAR; QSPR; deep learning; attention based models; transfer learning;

   Abstract : With the recent advantages of machine learning in cheminformatics, the drug discovery process has been accelerated; providing a high impact in the field of medicine and public health. Molecular property and activity prediction are key elements in the early stages of drug discovery by helping prioritize the experiments and reduce the experimental work. READ MORE

3. 7. The Benefits of the Placebo Effect in Serious Games : Possible Applications to Game Design

   University essay from Uppsala universitet/Institutionen för speldesign

   Author : Elly Ljungman; HM Muim Rahman; [2021]
   Keywords : Serious game design; Brain training game; Placebo response; Priming; Conditioning; Self-efficacy.; Seriös speldesign; Hjärnträning spel; Placeboeffekt; Priming; Betingning; Självförmåga.;

   Abstract : The presence of the placebo effect can be traced down both in the medical field and games. In the medical field, the placebo effect has been used to understand the effectiveness of any treatment or a specific drug given in a control group. If the medicine is working or it’s just the perceived improvement, which is the placebo effect. READ MORE

4. 8. Optimizing signal peptides for expression of recombinant antibodies in HEK293 cells

   University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

   Author : Gustav Myhrinder; [2020]
   Keywords : Signal peptide; antibody; mammalian cell; HEK293; secretory pathway;

   Abstract : Monoclonal antibodies are well-established as a therapeutic in the biopharmaceutical market, targeting a variety of diseases and with 79 approved products by the United States Food and Drug Administration in December 2019. Therapeutic monoclonal antibodies are commonly produced as recombinant proteins in mammalian cell lines, due to their capacity of post-translational modifications, most notably glycosylation. READ MORE

5. 9. CUSTOMIZED QUANTIFICATION OF HOST CELL PROTEIN WITH BIO-LAYER INTERFEROMETRY

   University essay from Lunds universitet/Teknisk mikrobiologi

   Author : Eva Sjöblom; [2020]
   Keywords : BLI; HCP; CHO; yeast; host cell protein; bio-layer interferometry; immunoassays; quantification; chinese hamster ovary; ELISA; applied microbiology; teknisk mikrobiologi; Biology and Life Sciences; Technology and Engineering;

   Abstract : Host cell protein (HCP) is quantified in the purification steps of biopharmaceutical production and is part of ensuring the purity of the final drug product. The gold standard method for HCP quantification is enzyme-linked immunosorbent assay (ELISA), but a new approach is proposed here with fully customized bio-layer interferometry assays for yeast and chinese hamster ovary (CHO) cells. READ MORE

6. 10. Fragment screening using WAC towards new SMARCA4 inhibitors

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Artur Sahakjan; [2020]
   Keywords : WAC; Fragments; SMARCA4; Library; Fragment Based Drug Discovery FBDD ; Peptide Synthesis; Affinity; Organic chemistry; Organisk kemi; Chemistry;

   Abstract : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. READ MORE