Essays about: "Clinical sequencing"
Showing result 26 - 30 of 47 essays containing the words Clinical sequencing.
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26. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. READ MORE
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27. Characterization of co-infections and minor variants of BK polyomavirus in clinical sample by NGS
University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologiAbstract : BK polyomavirus (BKV) is associated with urinary apparatus pathogenesis in kidney transplant recipient. Immune suppression triggers BKV reactivation that potentially causes polyomavirus associated nephropathy (PVAN), a major post-transplant problem causes graft rejection. READ MORE
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28. Coverage Analysis in Clinical Next-Generation Sequencing
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : With the new way of sequencing by NGS new tools had to be developed to be able to work with new data formats and to handle the larger data sizes compared to the previous techniques but also to check the accuracy of the data. Coverage analysis is one important quality control for NGS data, the coverage indicates how many times each base pair has been sequenced and thus how trustworthy each base call is. READ MORE
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29. Detection of artefacts in FFPE-sample sequence data
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Next generation sequencing is increasingly used as a diagnostic tool in the clinical setting. This is driven by the vast increase in molecular targeted therapy, which requires detailed information on what genetic variants are present in patient samples. READ MORE
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30. Evaluation of next-generation sequencing as a tool for determining the presence of pathogens in clinical samples
University essay from Högskolan i Skövde/Institutionen för biovetenskapAbstract : Metagenomic sequencing is an increasingly popular way of determining microbial diversity from environmental and clinical samples. By specifically targeting the 16S rRNA gene found in all bacteria, classifications of pathogens can be determined based on the variable and conserved regions found in the gene. READ MORE
