Essays about: "Gyrolab"

Showing result 6 - 10 of 15 essays containing the word Gyrolab.

1. 6. Effects of antibody labeling chemistry on assays developed for the Gyrolab immunoassay platform

   University essay from Uppsala universitet/Molekylär systembiologi

   Author : Julia Dencker; [2021]
   Keywords : Antibodies; Labeling chemistry; Site-specific labeling; Immunoassay; Gyrolab;

   Abstract : The aim of this project was to make a comparison of the effects of antibody labeling chemistries on assays developed for the Gyrolab immunoassay platform. One of the labeling techniques was a heterogenous labeling technique targeting amino groups on the antibody. READ MORE

3. 7. Development and comparison of three immunoassay formats to screen for total anti-adeno-associated virus serotype 2 antibodies in human serum using the Gyrolab immunoassay platform

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Elin Eriksson; [2020]
   Keywords : Adeno-associated virus; AAV; anti-AAV; TAb; Gyrolab; immunity; immunoassay;

   Abstract : Recombinant adeno-associated virus vectors are one of the most promising gene delivery tools for applications within gene- and cell therapy. The high level of wild-type adeno-associated virus infections in humans is a limitation due to the pre-existing immunity against the vector or its transgene product. READ MORE

4. 8. Evaluating Response Images From Protein Quantification

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Mathias Engström; Erik Olby; [2020]
   Keywords : Deep Learning; Protein Quantification; Gyros; Gyrolab; Automation; Image Processing; Simulation; CNN; DCNN; Image Simulation; Artefact Detection; Image Quality; Machine Learning; Image Classification;

   Abstract : Gyros Protein Technologies develops instruments for automated immunoassays. Fluorescent antibodies are added to samples and excited with a laser. This results in a 16-bit image where the intensity is correlated to concentration of bound antibody. READ MORE

5. 9. Development and comparison of bioanalytical methods to measure free analyte

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Alma Pihlblad; [2020]
   Keywords : Biotechnology; immunoassay; Gyrolab; ELISA; immunology; free analyte; overestimation; affinity; Avastin; bevacizumab; Lucentis; ranibizumab; VEGF; pharmacokinetic; pharmacodynamic;

   Abstract : Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. READ MORE

6. 10. Development of a method for kinetic characterisation of therapeutic antibodies in solution using the Gyrolab platform

   University essay from

   Author : Josef Pelcman; [2019]
   Keywords : kinetics; affinity; gyros; antibodies; antibody; kinetic; association; dissociation; affinity chromatography;

   Abstract : Therapeutic antibodies dominate the pharmaceutical market and improve the lives of millions of people annually. One important step when developing new medicines is to kinetically characterise the drug candidates. For antibodies this is difficult since many antibody reactions are extremely slow. READ MORE