Essays about: "pharmacodynamic"
Showing result 1 - 5 of 20 essays containing the word pharmacodynamic.
-
1. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models
University essay from Uppsala universitet/Institutionen för farmaciAbstract : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. READ MORE
-
2. Design and analysis of pre-clinical experiments using a method combining multiple comparisons and modeling techniques for dose-response studies
University essay from Göteborgs universitet/Institutionen för matematiska vetenskaperAbstract : Abstract. Identifying and estimating the dose-response relationship between a compound and a pharmacological endpoint of interest is one of the most important and difficult goals in the preclinical stage of pharmaceutical drug development. READ MORE
-
3. Mathematical model for the change of the protein profiles in urine during the bladder cancer development
University essay from Uppsala universitet/Institutionen för farmaciAbstract : Most patients with bladder cancer are in the stage of non-muscle-invasive bladder cancer (NMIBC), while 30% of patients progress to the life-threatening muscle-invasive bladder cancer (MIBC) stage because of distant metastases. The selection of treatment options depends on the bladder cancer stage. READ MORE
-
4. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study
University essay from KTH/Medicinteknik och hälsosystemAbstract : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. READ MORE
-
5. Development and comparison of bioanalytical methods to measure free analyte
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. READ MORE