Essays about: "Structural bioinformatics"

Showing result 6 - 10 of 18 essays containing the words Structural bioinformatics.

  1. 6. Transcriptional changes in stem cell-derived cardiomyocytes during extended cell cultures

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Michel Jonathan Speh; [2020]
    Keywords : ;

    Abstract : The recent advancement in the field of stem cell research gave rise to high expectations from both general and scientific audiences, and indeed, stem cells and stem cell-derived cells have an enormous potential to forward the fields of medical research and regenerative medicine. Nevertheless, there are still many obstacles and limitations associated with stem cell technology. READ MORE

  3. 7. Clustering approaches for extracting structural determinants of enzyme active sites

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Ismini - Christina Stamatelou; [2020]
    Keywords : Structural bioinformatics; enzyme; active site; glycogen phosphorylase; clustering; rotamer; conformation; k-means; clara;

    Abstract : The study of enzyme binding sites is an essential but rather demanding process of increased complexity since the amino acids lining these areas are not rigid. At the same time, the minimization of side effects and the specificity of new ligands is a great challenge in the structure-based drug design approach. READ MORE

  4. 8. Whole-Genome Sequencing of two Swedish Individuals on PromethION

    University essay from Lunds universitet/Examensarbeten i bioinformatik

    Author : Nazeefa Fatima; [2019]
    Keywords : Biology and Life Sciences;

    Abstract : Background: Chromosomes can undergo various changes such as deletions, inversions, insertions, and/or translocations resulting in structural variation differences between individuals. Structural variants are a common source of variability in the human genome and have been known to be associated with common diseases such as autism, cancer, and rare human diseases [1, 2]. READ MORE

  5. 9. Modifying a Protein-Protein Interaction Identifier with a Topology and Sequence-Order Independent Structural Comparison Method

    University essay from Linköpings universitet/Bioinformatik

    Author : Joakim Johansson; [2018]
    Keywords : PPI; Protein-protein interaction; Machine learning; Protein modelling; Structural bioinformatics; Structural alignment; Sequence-order independent;

    Abstract : Using computational methods to identify protein-protein interactions (PPIs) supports experimental techniques by using less time and less resources. Identifying PPIs can be made through a template-based approach that describes how unstudied proteins interact by aligning a common structural template that exists in both interacting proteins. READ MORE

  6. 10. Identifying Pathogenic Amino Acid Substitutions in Human Proteins Using Deep Learning

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Alexander Kvist; [2018]
    Keywords : Bioinformatics; deep learning; proteomics; mutations; single nucleotide polymorphism; SNP; convolutional neural network; variant effect prediction;

    Abstract : Many diseases of genetic origin originate from non-synonymous single nucleotide polymorphisms (nsSNPs). These cause changes in the final protein product encoded by a gene. Through large scale sequencing and population studies, there is growing availability of information of which variations are tolerated and which are not. READ MORE