Essays about: "x-ray protein"

Showing result 1 - 5 of 39 essays containing the words x-ray protein.

  1. 1. Acoustic Focusing of Lysozyme Crystals

    University essay from KTH/Tillämpad fysik

    Author : Måns Junestrand; [2023]
    Keywords : Protein Crystals; Lysozyme Crystals; Ultrasound; Acoustic Focusing; SFX; Biomedical Physics; Proteinkristaller; Ultraljud; Lysozymkristaller; Akustisk fokusering; SFX; Biomedicinsk fysik;

    Abstract : Acoustic focusing of microscale protein crystals with acoustophoresis technology could reduce clogs during experiments with the scientific technique serial femtosecond x-ray crystallography (SFX). SFX determines molecular structures of proteins, these structures are valuable in drug discovery and fundamental biomedical research. READ MORE

  2. 2. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    University essay from KTH/Tillämpad fysik

    Author : Samuel Eriksson Lidbrink; [2023]
    Keywords : AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Abstract : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. READ MORE

  3. 3. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Javier Lagares Martín; [2023]
    Keywords : Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

    Abstract : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. READ MORE

  4. 4. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    University essay from Lunds universitet/Kemiteknik (CI)

    Author : Owais Khalil; [2023]
    Keywords : Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Abstract : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. READ MORE

  5. 5. Expression and purification of pyruvate transporting human mitochondrial pyruvate carrier (MPC) protein complex for structural studies

    University essay from Lunds universitet/Examensarbeten i molekylärbiologi

    Author : Markus Wendler; [2022]
    Keywords : Biology and Life Sciences;

    Abstract : Pyruvate is one of the main molecules needed for the citric acid cycle, which produces energy in the form of ATP. The citric acid cycle reaction occurs in the mitochondrial matrix, and for pyruvate to participate in the reaction, it needs to be transported from the cytosol across the mitochondrial membranes into the mitochondrial matrix. READ MORE