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Showing result 1 - 5 of 7 essays matching the above criteria.

  1. 1. Identifying effects of adrenaline and dopamine binding on the beta2-adrenergic receptor structure and function using machine learning

    University essay from KTH/Skolan för teknikvetenskap (SCI)

    Author : Joar Gunnarsson; Leon Bergner; [2023]
    Keywords : beta2-adrenergic receptor; GPCR; adrenaline; dopamine; Machine learning; Molecular dynamics simulation;

    Abstract : The beta2-adrenergic receptor is a G-protein coupled receptor, involved in several physiological processes, which enables signaling through the cell membrane. To study the effect of dopamine and adrenaline binding on the receptor structure and function, we used machine learning methods applied to data from molecular dynamics simulations. READ MORE

  3. 2. Approaches to Structural Characterization of a Heteromeric GABA(A)R

    University essay from KTH/Tillämpad fysik

    Author : Alexander Stevens; [2023]
    Keywords : Applied Physics; Biophysics; Molecular Biophysics; GABA A R; LGIC; pLGIC; Tillämpad Fysik; Biofysik; Molekylär Biofysik; GABA A R; LGIC; pLGIC;

    Abstract : Structural biology has become an important part of researching various diseases and drug development. In this thesis, I provide details on how I worked with approaches to structural characterization of a heteromeric GABA(A)R. READ MORE

  4. 3. Structural features underlying antigen presentation by the non-classical MHC class Ib molecule Qa-1b

    University essay from KTH/Proteinvetenskap

    Author : Lejla AI-Tamimi; [2022]
    Keywords : immune checkpoint; NKG2A; MHC class Ib; Qdm; antibody; crystal structure;

    Abstract : Blockering av NKG2A receptorn på NK - och CD8+ T celler med en anti-NKG2A antikropp, medför en aktivering av cytolytisk aktivitet, och är en lovande immunkontrollpunkt i immunterapi mot cancer. Nyligen har en TCR-liknande antikropp, EXX1, som binder till liganden för NKG2A receptorn, Qa-1b - en icke-klassisk MHC klass Ib molekyl i möss -studerats i tumör modeller in vitro. READ MORE

  5. 4. Characterisation of Potential Inhibitors of Calmodulin from Plasmodium falciparum

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Alexandra Iversen; Ebba Nordén; Julia Bjers; Filippa Wickström; Martin Zhou; Mohamed Hassan; [2020]
    Keywords : Plasmodium falciparum; Calmodulin; Malaria; Trifluoperazine; Calmidazolium; Artemisinin; Fentanyl derivatives; Modelling; Docking; Bioinformatics;

    Abstract : Each year countless lives are affected and about half a million people die from malaria, a disease caused by parasites originating from the Plasmodium family. The most virulent species of the parasite is Plasmodium falciparum (P. falciparum). READ MORE

  6. 5. Mutational engineering, growth selection, expression, purification and crystallization of ligand bound endo-beta-N-acetylglucosaminidase T (Endo-T) from Hypocrea jecorina

    University essay from SLU/Dept. of Molecular Biology (until 131231)

    Author : Andreas Digre; [2010]
    Keywords : Endo-T; Endo-beta-N-acetylglucosaminidase; Deglycosylation; EC 3.2.1.96; Crystallography; Ligand bound structure; High mannose N-glycan; HPAEC-PAD;

    Abstract : Recently, one of the first fungal-expressed, deglycosylating, Endo-beta-N-acetylglucosaminidases was found in the extracellular medium of soft-rot ascomycete Hypocrea jecorina (a.k.a. Trichoderma reesei) belonging to glycoside hydrolase family 18 (GH18). READ MORE