Essays about: "Cryo-TEM"

Showing result 1 - 5 of 7 essays containing the word Cryo-TEM.

1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

   University essay from Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

   Author : Elina Edidovica; [2024]
   Keywords : Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

   Abstract : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. READ MORE

3. 2. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

   University essay from Lunds universitet/Kemiteknik (CI)

   Author : Owais Khalil; [2023]
   Keywords : Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

   Abstract : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. READ MORE

4. 3. Aqueous self-assembly behaviour alteration derived from primary structure changes of model peptides

   University essay from Lunds universitet/Kemiska institutionen

   Author : Marcus Bäcklund; [2020]
   Keywords : Model peptides; self-assembly; SAXS; FTIR; CD; physical chemistry; fysikalisk kemi; Chemistry;

   Abstract : Understanding of the self-assembly behaviour of peptides is of great interest within several different areas such as neurodegenerative diseases, biotechnology, and peptide pharmaceuticals. In this work we have compared the impact on the self-assembly behaviour derived from systematic changes of the primary structure of A8K, where A denotes alanine and K lysine. READ MORE

5. 4. Lipid liquid crystalline phase and starch particle mixed formulations

   University essay from Lunds universitet/Kemiska institutionen

   Author : Cindy Phan; [2018]
   Keywords : physical chemistry; fysikalisk kemi; lipid liquid crystals; starch; cubic phase; Chemistry;

   Abstract : Lipid liquid crystals (LLC) have been studied widely because of their broad application in both food- and pharmaceutical industry. Inverse bicontinuous cubic phase of LLC have been of particular interest as it has three-dimensional structure and has been proven to be able to incorporate and deliver substances (e.g. topical drug delivery). READ MORE

6. 5. Hexosomes as Drug Delivery Vehicles for Antimicrobial Peptides

   University essay from KTH/Skolan för kemivetenskap (CHE)

   Author : SZYMON SOLLAMI DELEKTA; [2015]
   Keywords : hexosome; peptide; antimicrobial; QCM; bacterial;

   Abstract : This master thesis project was carried out at SP Technical Research Institute of Sweden within the FORMAMP project which goal is to increase the efficiency and stability of antimicrobial peptides (AMPs) by exploring and developing a number of innovative formulation strategies for the drug delivery of those systems. In view of the growing problem of bacterial resistance to traditional antibiotics, AMPs represent one of the most promising alternatives as therapeutics against infectious diseases: besides having a fast and non-specific mechanism of action, they are less prone to bacterial resistance. READ MORE