Essays about: "Ubiquitination"

Found 5 essays containing the word Ubiquitination.

1. 1. Development of biophysical methods for characterization of PROTACs

   University essay from Uppsala universitet/Biokemi

   Author : Westlin Oskar; [2021]
   Keywords : ;

   Abstract : Targeting protein with the aim of ubiquitin-labelling for degradation is a new and upand coming field of drug discovery. Proteolysis targeting chimeras (PROTACs) areheterobifunctional linker molecules that connects the target molecule to an E3ubiquitin ligase, subsequent ubiquitination of the target protein initiates the proteindegradation by the proteosome system. READ MORE

3. 2. Histone modifications and their role in splicing

   University essay from Linköpings universitet/Biologi

   Author : Anna Wettermark; [2020]
   Keywords : Splicing; Spliceosome; Histone modifications; epigenetics; histone methylation; histone acetylation; histone phosphorylation; histone ubiquitination;

   Abstract : Splicing is the process when introns gets removed and exons are spliced together. This is an important step to form a clean mRNA with no unnecessary sequences that could interrupt protein synthesis. There are different types of splicing and some of them need a complex called spliceosome. READ MORE

4. 3. Identification of Novel Regulators of Mitochondrial Protein Quality Control

   University essay from Lunds universitet/Tillämpad biokemi

   Author : My Bratbakken Lundvall; [2015]
   Keywords : Mitochondrial Quality Control; Oxidative Stress; Ubiquitin ligases; Ubiquitin; Yeast; Parkinson s Disease; Mitochondria; Paraquat; Oxidative Damage; Superoxides; tillämpad biokemi; applied biochemistry; Technology and Engineering; Chemistry; Biology and Life Sciences;

   Abstract : Chronic pesticide exposure has been linked to several human diseases including cancer, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, cardiovascular disease, and kidney disease. Due to the potential risks to human health, the usage of pesticides has been a controversial topic. READ MORE

5. 4. Ro52 : Structure and interactions of constructs of RING and B-box

   University essay from Linköpings universitet/Teknisk biologi; Linköpings universitet/Tekniska högskolan

   Author : Emmy Österberg; [2014]
   Keywords : Structural biology; Ro52; TRIM21; Ubiquitination; Western blot; Protein expression; Protein purification;

   Abstract : The ubiquitination process is vital to maintain the protein homeostasis in the cell. With high specificity it regulates degradation of proteins by tagging them with a small protein called ubiquitin. Four proteins are involved to perform the process and in this thesis one of these proteins is studied. READ MORE

6. 5. Histone modifications after DNA damage affect survival in Schizosaccharomyces pombe

   University essay from Institutionen för livsvetenskaper

   Author : Abdul Mateen Rajput; [2010]
   Keywords : Epigenetics; DNA damage; S. pombe; yeast; histone modification; chromatin; life sciences; gene deletion; gene tagging; pcr; mms; 4-nqo; brl1; brl2; Epigenetics، ڈی این اے کو نقصان، ایس pombe، خمیر، histone تبدیلی، chromatin، زندگی سائنس، جین خارج، جین ٹیگنگ، پی سی آر، ایم ایم ایس،; Epigenetik; DNA-skada; S. pombe; jäst; histon modifiering; kromatin biovetenskap; gendeletion; gen taggning; PCR; MMS; 4-nqo; brl1; brl2;

   Abstract : S. cerevisiae Ada2 and Bre1 has a role in histone post-translational modifications. Deletion of these genes causes deficiency in acetylation (Ada2) or ubiquitination (Bre1) of histones. Further, mutants lacking these genes or homologous genes showed different phenotypes in human and S. READ MORE